Laboratory Specialty Services
Crescent Chemical Co Inc SERVALYT™ 4-5
SERVALYT™ 4-5 40 % (w/v) solution in water SERVALYT™ Carrier Ampholytes (40 % w/v in water). Standard quality (analytical grade) for general use in IEF. Size - 25ML Storage Conditions - +2 °C TO +8 °C Catalog Number - 42923.02
Apexbio Technology LLC Compound 56 171745-13-4 500ug
Compound 56 (CAS 171745-13-4) known as 4-[(3-bromophenyl)amino]-6 7-diethoxyquinazoline is a highly potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with an IC50 of 0 006 nM It competitively binds to the ATP-binding site of EGFR blocking EGF-dependent receptor phosphorylation Compound 56 suppresses proliferation and colony formation in human cancer cell lines that overexpress EGFR and inhibits EGF-mediated mitogenesis and oncogenic transformation in fibroblasts with EGFR overexpression It also shows moderate inhibition of HER2/neu tyrosine kinase This compound is widely used to investigate EGFR signaling and function in cancer research
Apexbio Technology LLC TAK-285 871026-44-7 10mM (in 1mL DMSO)
TAK-285 (CAS 871026-44-7) is a small molecule inhibitor targeting the receptor tyrosine kinases HER2 and EGFR with reported IC50 values of 17 nM and 23 nM respectively Both HER2 and EGFR are members of the ErbB receptor family frequently implicated in tumorigenesis through overexpression in various cancers TAK-285 demonstrates selective inhibition of cancer cell lines overexpressing HER2 or EGFR while sparing cells with normal expression levels In xenograft models TAK-285 administration significantly reduced tumor growth Additionally the compound inhibits downstream signaling by suppressing AKT and MAPK phosphorylation TAK-285 serves as a valuable tool for investigating HER2/EGFR-driven oncogenic mechanisms and for evaluating therapeutic strategies targeting these pathways
Cambridge Isotope Laboratories HRMS rapid PCB Screening Calibration Solution (CS0 05) 0 2 mL
HRMS rapid PCB Screening Calibration Solution (CS0 05) 0 2 mL
Cambridge Isotope Laboratories Rapid PCB Screening Calibration Solution (CS1) 0 2 mL
Rapid PCB Screening Calibration Solution (CS1) 0 2 mL
Selleck Chemical LLC Compound 401
Compound 401 is a synthetic inhibitor of DNA-PK(IC50 0 28 M) and mTOR (IC50 5 3 M) It has no inhibition on p110 /p85 PI3K ( 100 M) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells
Apexbio Technology LLC SGI-1027 1020149-73-8 100mg
SGI-1027 (CAS 1020149-73-8) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) exhibiting IC50 values of 12 5 M for DNMT1 8 M for DNMT3A and 7 5 M for DNMT3B It acts by competitively inhibiting the cofactor Ado-Met binding site rather than the DNA substrate site resulting in reduced DNMT activity and subsequent inhibition of DNA methylation SGI-1027 suppresses both mammalian and bacterial DNMTs affecting endogenous and recombinant forms In cancer cell models it induces demethylation of CpG islands in gene promoter regions leading to reactivation of silenced tumor suppressor genes such as P16 and TIMP3 and promotes DNMT1 degradation via the proteasome pathway SGI-1027 is utilized in epigenetics research to study DNA methylation dynamics and gene reactivation
Crescent Chemical Co Inc SERVALYT™ 3-10 ISO-DALT
SERVALYT™ 3-10 Iso-Dalt 40 % (w/v) solution in water Iso-Dalt quality; special 2D grade to be used in 2D electrophoresis. Size - 25ML Storage Conditions - +2 °C TO +8 °C Catalog Number - 42951.02
Selleck Chemical LLC Isoeugenol
Isoeugenol (4-Propenylguaiacol) an essential oil constituent of nutmeg clove and cinnamon shows antimicrobial activity
eMolecules 1013101-36-4 | PF-04691502 | MFCD18782794 | 0.1g
Pharmablock | azetidin-3-amine dihydrochloride | 500mg | 551060390 | PB01212 | 102065-89-4 | MFCD09910173 | 145.030 | C3H10Cl2N2
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Medchemexpress LLC Bay-3827 | 2377576-35-5 | 99.72% | 468.53 | 50 MG
BAY-3827 is a chemical probe that functions as a potent and selective AMPK inhibitor. It exhibits IC50 values of 1.4 nM at low ATP concentration (10 μM) and 15 nM at high ATP concentration (2 mM). This compound shows over 500-fold selectivity for most of the 331 kinases, preventing phosphorylation of acetyl-CoA carboxylase 1 and demonstrating significant anti-proliferative activity in androgen-dependent prostate cancer cell lines.
- Potent and selective AMPK inhibitor
- Shows over 500-fold selectivity for most of 331 kinases
- Prevents phosphorylation of acetyl-CoA carboxylase 1
- Demonstrates anti-proliferative activity in androgen-dependent prostate cancer cell lines
Medchemexpress LLC Lit-927 | 2172879-52-4 | 99.9% | 328.75 | 1 ML
LIT-927 is a locally and orally active CXCL12 neutraligand with anti-inflammatory effect, with a Ki of 267 nM for CXCL12 binding to its specific receptor CXCR4.